Uridine 5’-Monophosphate Disodium Salt: What is it and where is it used?

In the dietary supplement world, there is growing interest in the potential benefits of uridine 5-monophosphate disodium salt. With its unique properties and potential health benefits, it has become a popular choice among individuals seeking to support overall health. Aogu Biotech is a company specializing in the production and sale of pharmacologically active substances, raw materials and plant extracts, and is at the forefront of providing high-quality uridine 5-monophosphate disodium salt to the dietary supplement industry.

What Is Uridine 5’-Monophosphate Disodium Salt?


Uridine 5’-monophosphate disodium salt (UDP-MS) is a specific form of uridine 5’-monophosphate (UMP) modified to enhance its stability and solubility. It is a disodium salt derivative of UMP, meaning that sodium ions replace the two hydrogen ions of the phosphate group.

UDP-MS is widely used in research, pharmaceutical, and nutritional supplement applications. It offers improved water solubility compared to UMP, making dissolving in aqueous solutions and formulations easier.

As a nucleotide, UDP-MS plays a crucial role in various biological processes. It is a building block for RNA synthesis and produces energy-rich molecules like ATP (adenosine triphosphate). UDP-MS is also a key component in cellular signaling pathways, acting as a donor of sugar moieties for glycosylation reactions.

UDP-MS is often sought in nutritional supplements for its potential cognitive-enhancing and neuroprotective properties. It is believed to contribute to brain function by increasing the production of neurotransmitters, promoting neuronal growth, and supporting synaptic plasticity. Additionally, UDP-MS has been investigated for its potential benefits in memory enhancement, cognitive disorders, and neurological conditions.

When purchasing UDP-MS as a powder, it is essential to consider the purity specification. The standard specification of “pure Uridine 5’-Monophosphate disodium salt 99% powder” indicates that the product comprises at least 99% UDP-MS, with the remaining 1% primarily composed of related impurities. High purity ensures the quality and effectiveness of the UDP-MS supplement.

What Is Uridine 5-Monophosphate Made From?

Uridine 5-monophosphate (UMP) is a nucleotide synthesized from several precursors within the body. The primary precursors involved in UMP synthesis are:

  • 1. Ribose-5-phosphate: Ribose-5-phosphate is a sugar molecule derived from the pentose phosphate pathway, a metabolic pathway that occurs in the cells. It serves as the backbone of the UMP molecule.
  • 2. Orotate: Orotate, or orotic acid, is a heterocyclic compound with a pyrimidine ring structure. Orotate serves as the base moiety in UMP, specifically the uracil base.
  • 3. Phosphate group: Phosphate groups, consisting of phosphorus and oxygen atoms, are acquired from various sources within the body, including adenosine triphosphate (ATP) and other phosphate-containing compounds.

The synthesis of UMP involves a series of enzymatic reactions within the body. Ribose-5-phosphate combines with orotate through a reaction catalyzed by the orotate phosphoribosyltransferase, forming orotidine 5’-monophosphate (OMP). OMP is further transformed into UMP through the orotidylate decarboxylase, which removes a carboxyl group from OMP.

It’s worth noting that UMP can also be obtained through dietary sources. Foods rich in nucleotides, such as organ meats, fish, and certain vegetables, can contribute to the intake of UMP precursors. However, the body can synthesize UMP de novo using the aforementioned metabolic pathways.

Once UMP is synthesized, it is a critical component in RNA biosynthesis, acting as a building block for RNA molecules during transcription. UMP also plays a role in various physiological processes and synthesizes phospholipids and other important cellular compounds.

Overall, the synthesis of UMP relies on the availability of ribose-5-phosphate, orotate, and phosphate groups derived from metabolic pathways and cellular sources within the body.

What are the benefits of uridine 5 monophosphate disodium salt?

Uridine 5’-monophosphate disodium salt (UDP-MS) offers several potential benefits due to its properties as a nucleotide and its enhanced solubility. Here are some of the potential benefits associated with UDP-MS:

Uridine 1
  • Cognitive Enhancement: UDP-MS is believed to have cognitive-enhancing effects similar to Uridine 5’-monophosphate (UMP). It plays a role in promoting neuronal growth, supporting synaptic plasticity, and enhancing brain function. UDP-MS may improve cognitive performance, memory, and learning abilities by increasing the production of neurotransmitters such as dopamine, acetylcholine, and norepinephrine.
  • Neuroprotection: UDP-MS has been investigated for its potential neuroprotective properties. It may help protect brain cells against oxidative stress and neuroinflammation associated with neurodegenerative diseases and age-related cognitive decline. The enhanced solubility of UDP-MS can facilitate its delivery and potential efficacy in protecting neuronal health.
  • Mood Regulation: UDP-MS may have mood-regulating effects by modulating the levels of neurotransmitters involved in mood regulation, such as dopamine and serotonin. By influencing the balance of these neurotransmitters, UDP-MS can contribute to a more balanced and positive mood.
  • Liver Health: UDP-MS has been studied for its potential hepatoprotective properties. It may help protect liver cells against damage and support liver function. UDP-MS can play a role in synthesizing phospholipids, which is crucial for maintaining cell membrane integrity and liver health.
  • Energy Metabolism: As a nucleotide, UDP-MS participates in cellular energy metabolism. It produces adenosine triphosphate (ATP), the principal energy currency for cellular activities. UDP-MS has the potential to enhance cellular function and energy production by facilitating the process of ATP synthesis.


  • Drug Intermediates

Degradation products of RNA (Nucleotides, nucleosides and nucleic acid bases) are all medicines with a wide application, and their derivatives have more remarkable application in the fields of antivirus and anti tumors. It has been widely applied in the treatment of hepatitis, gastritis, coronary heart disease, rheumatoid arthritis, leukocytopenia, cerebral concussion, angiocardiopathy etc.

  • Food Additives

Milk powder added with nucleotides not only can improve the development of gastrointestinal tract of infants, but also improve the immunological function of intestinal cells so that build up the resistance to bacterial infection. The addition of nucleotides into functional foods would help people delay aging, extend life and improve immunity etc. Additionally, there has been a wide application of flavor nucleotides in food seasoning.

  • Feed Additives

Nucleotide is a kind of non-toxic and harmless feed additive, improving animal’s immune, gastrointestinal function and fat metabolism. Such as, nucleotides can increase the feed rate of pig, improve laying rate of chicken, promoting the growth and reproduction of fishes and aquatic animals.

In conclusion, the potential benefits of uridine 5-monophosphate disodium salt make it an important ingredient in dietary supplements. With its expertise in the production and sale of pharmacologically active substances, Julyherb is committed to providing high-quality uridine 5-monophosphate disodium salt to the dietary supplement industry. With its potential cognitive and neurological benefits, as well as its role in supporting overall cellular function and energy metabolism, uridine 5-monophosphate disodium salt has become a popular choice for individuals seeking to support overall health, and this is why Not surprising.

Julyherb is committed to providing the highest quality uridine 5-monophosphate disodium salt for dietary supplements. Their dedication to quality and purity ensures people can trust the products they consume. As a company specializing in the production and sale of pharmacologically active substances, raw materials and plant extracts, Julyherb is well-positioned to meet the growing demand for uridine 5-monophosphate disodium salt in the dietary supplement industry.