L-Rhamnose Monohydrate for Intestinal Permeability


L-Rhamnose Monohydrate is a naturally-occurring deoxy sugar used widely in the field of food and beverage production. The compound also finds application in the cosmetic industry as it is shown to provide anti-aging effects among individual users. L-Rhamnose Monohydrate is also beneficial in the production of perfumes and fragrances.

What is L-rhamnose Monohydrate?

L-Rhamnose Monohydrate is a rare monosaccharide compound that is a common glycone component of several glycosides. The compound is found in both plants and bacteria. Essentially, it is responsible for maintaining the cellular wall structure of its plant sources.  It is also important in the manufacture of drugs and other pharmaceutical products as it can remove excess periodate in glycerol and other vicinal diol analysis. L-Rhamnose Monohydrate is also useful in assaying intestinal permeability.

L-Rhamnose Monohydrate appears as a white crystalline granule or a white crystalline powder when used in various applications. It is essentially soluble in water and methanol, but only sparingly soluble in ethanol.

Other names for the compound include 6-Deoxy-L-mannose, L-Rha • H2O, L(+)-Rhamnose Monohydrate, and Flucloxacillinsodium. It is described as having CAS number 6155-35-7 and molecular formula C6H14O6. The molecular weight of the compound is 182.17 g/mol.


Sources of L-rhamnose Monohydrate

Generally, L-rhamnose Monohydrate powder is derived from the hydrolytic liquid of Quercitin. Rhamnose is naturally obtained from Buckthorn, poison sumac, and plants in the genus Uncaria. The most common herbal source of L-rhamnose Monohydrate is Sophora japonica L. This is also the plant source for L-rhamnose Monohydrate powder sold at julyherb.com, a legitimate online supplier of ingredients for dietary supplement formulations and other essential industry applications.

How does L-rhamnose Monohydrate work?

As a sugar compound, L-rhamnose Monohydrate is believed to play vital roles in certain biological pathways. Aside from being an important component of microbial and plant cell wall structure, the L-rhamnose Monohydrate may be used in the production of some rare sugars such as L-talose and L-mannose. It is also believed that the compound may stimulate cellular proliferation and transmission of messages between cells through the addition of Rhamnose-Rich Oligo- and Polysaccharides to fibroblasts.

When combines with lipids, L-rhamnose Monohydrate also leads to the production of biosurfactants and emulsifiers. As a result, L-rhamnose Monohydrate may help improve the solubility and stability of other compounds in cosmetic products and dietary supplements.

L-Rhamnose Monohydrate benefits

The use of L-rhamnose Monohydrate may provide various benefits which include the following:

  • It may be used in skincare products

Modern cosmetic and skincare products usually include relative quantities of L-rhamnose Monohydrate. This is because the compound helps reduce the surface tension of some liquids by acting as a surfactant. The use of L-rhamnose Monohydrate may improve the texture and consistency of cosmetic and skincare products. It may also improve the stability of compounds in these products for the said compounds to provide desired effects easier.

Also, rhamnolipids or the combination of L-rhamnose Monohydrate or Rhamnose with lipids are now used in anti-aging and anti-wrinkle products.

  • It serves as an artificial sweetener

The compound is also used widely as a sugar substitute in food and beverage production. Accordingly, the compound is about 33% as sweet as sucrose or table sugar.

  • It is used to determine intestinal permeability

One of the most common applications of L-rhamnose Monohydrate is in assaying intestinal permeability. The compound is usually combined with lactulose to determine permeability in the small intestines as they are commonly broken down in the cecum by colonic bacteria.

L-Rhamnose Monohydrate is also among the disaccharides which are used to assess transcellular and paracellular transport capacity across the intestinal mucosa.

  • L-Rhamnose Monohydrate Acceptable Daily Intake

In general, the recommended Acceptable Daily Intake for L-rhamnose Monohydrate and other glycosides is at 0-2mg/kg body weight. However, persons who are taking medications for certain diagnosed disorders should consult their physicians as the compound may cause certain drug interactions. The Acceptable Daily Intake for the compound may also vary depending on the individual user’s age, weight, and overall physical condition.

Rhamnose is a key anti-aging ingredient that can reduce signs of aging with no cutting or poking necessary. It works magic by targeting the papillary dermis, the thin layer under the dermo-epidermal junction. It is clinically proven to improve collagen and elastin production as well as cellular turnover.

Rhamnose is a key anti-aging ingredient that can reduce signs of aging with no cutting or poking necessary. It works magic by targeting the papillary dermis, the thin layer under the dermo-epidermal junction.